Profile: Gerald D. Frenkel

Professor

Faculty
Department of Biological Sciences

Cancer Biology

Effects of selenium compounds on tumors in vivo and tumor cells in vitro — Selenium compounds as cancer chemotherapeutic and chemopreventive agents — Prevention of drug resistance in cancer.

  • Education

    Ph.D. in Biological Chemistry, Harvard University, 1971.

  • Publications

    Caffrey, P.B., and Frenkel, G.D.  (2012).  Selenite enhances and prolongs the efficacy of Cisplatin treatment of human ovariam tumor xenografts.  In Vivo 26: 549-552.

    Caffrey, P.B. and Frenkel, G.D. (2001) A prevention strategy for circumventing drug resistance in cancer chemotherapy. Current Pharmaceutical Design 7:1595-1614.

    Caffrey, P.B. and Frenkel, G.D. (2000) Selenium compounds prevent the induction of drug resistance by cisplatin in human ovarian tumor xenografts in vivo. Cancer Chemother. Pharmacol. 46: 74-78.

    Caffrey, P.B., Zhu, M., Zhang, Y., Chinen, N. and Frenkel, G.D. (1999) Rapid development of glutathione S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid. Cancer Letters 136: 47-52.

    Caffrey, P.B. and Frenkel, G.D. (1998) Treatment of human ovarian tumor xenografts with selenite prevents the development of melphalan-induced drug resistance. Anticancer Research 18: 3017-3020.

    Caffrey, P.B., Zhang, Y. and Frenkel, G.D. (1998) Rapid development of drug resistance in human ovarian tumor xenografts after a single treatment with melphalan in vivo. Anticancer Research 18: 3021-3026.

    Caffrey, P.B., Zhu, M. and Frenkel, G.D. (1998) Prevention of the development of melphalan resistance in vitro by selenite. Biological Trace Element Research, 65: 187-196.

    Zhu, M., Gong, Y. and Frenkel, G.D. (1998) Studies on the mechanism of the selenite-induced decrease in cell attachment: effect of selenite on the levels of fibronectin receptor (a5b1 integrin) mRNAs. Biological Trace Element Research 62: 123-134.

    Caffrey, P.B. and Frenkel, G.D. (1997) Sensitivity of melphalan-resistant tumors to selenite in vivo. Cancer Letters 121: 177-180.

    Yan, L. and Frenkel, G.D. (1994) Effect of selenite on cell surface fibronectin receptor. Biological Trace Element Research 46:79-89.

    Caffrey, P.B. and Frenkel, G.D. (1994) The development of drug resistance by tumor cells in vitro is accompanied by the development of sensitivity to selenite. Cancer Letters 81:59-65.

    Gong, Y. and Frenkel, G.D. (1994) Effect of selenite on tumor cell invasiveness. Cancer Letters 78:195-199.

    Yan, L. and Frenkel, G.D. (1992) Inhibition of cell attachment by selenite. Cancer Research 52:5803-5807.

    Caffrey, P.B. and Frenkel, G.D. (1992) Selenite cytotoxicity in drug resistant and non-resistant human ovarian tumor cells. Cancer Research 52:4812-4816.