Profile: Ann Cali

Professor

Faculty
Department of Biological Sciences

 

As a comparative pathobiologist/protistologist, my laboratory specializes in the study of obligate intracellular parasitic organisms of the phylum, Microsporidia, in all types of hosts including invertebrates, vertebrates, and humans.  We study many aspects of the biology of the microsporidian parasites especially their ultrastructure, specialized and/or unique organelles, development and pathology as well as their distribution, means of transmission, and identification.  We study these parasites in vivo and/or in vitro in cell cultures as the microsporidia cannot be cultivated outside host cell cytoplasm.  Our understanding of animal infections provides insights into human infection, as well as epidemiology, reservoir hosts, and transmission to humans.

  • Education

    B.A. in Biology, University of Florida.

    Ph.D. in Zoology and Entomology, Ohio State University.

  • Publications

    Takvorian, PM, Buttle, KF, Mankus, D, Mannella, CA, Weiss LM, and A Cali.  2013.  The multilayered interlaced network (MIN) in the sporoplasm of the microsporidium Anncaliia algerae is derived from Golgi.  J Eukaryotic Microbiology 2013 Mar-Apr;60(2):166-178.

    Sanders J, Myers MS, Tomanek L, Cali A, Takvorian PM, and ML Kent.  2012.  Ichthyosporidium weissii n. sp (Microsporidia) infecting the arrow goby (Clevelandia ios).  J Eukaryotic Microbiology 2012 May-Jun;59(3):258-267.

    Ghosh K, Nieves E, Keeling P, Cali A, and LM Weiss.  2012.  A new vesicular compartment in Encephalitozoon cuniculi.  Microbes and Infection 2012 Apr;14(4):324-328.

    Cali A, Kent M, Sanders J, Pau C, and P Takvorian.  2012.  Development, ultrastructural pathology, and taxonomic revision of the microsporidial genus, Pseudoloma and its type species Pseudoloma neurophilia, in skeletal muscle and nervous tissue of experimentally infected zebrafish Danio rerio.  J Eukaryotic Microbiology 2012 Jan-Feb;59(1):40-48.

    Ghosh K, Nieves E, Keeling P, Pombert JF, Henrich PP, Cali A, and Weiss LM. 2011.  Branching network of proteinaceous filaments within the parasitophorous vacuole of Encephalitozoon cuniculi and Encephalitozoon hellem.  Infect Immun. 2011 Mar;79(3):1374-85. [Link]

    Cali A, Neafie R, Weiss LM, Ghosh K, Vergara RB, Gupta R, and Takvorian PM.  2010.  Human Vocal Cord Infection with the Microsporidium Anncaliia algerae.  J Eukaryot Microbiol. 2010 Nov-Dec;57(6):562-7. [Link]

    Bouzahzah B, Nagajyothi F, Ghosh K, Takvorian PM, Cali A, Tanowitz HB, and Weiss LM.  2010.  Interactions of Encephalitozoon cuniculi polar tube protein. Infection and Immunity 78(6):2745-53. [Link]

    Cali, A. and Takvorian, P.M.  2010.  Microsporidia. In Handbook of Protoctista, Second edition. Lynn Margulis, Editor. Jones and Bartlett, Boston. In press.

    Williams, B., Cali, A., Takvorian, P.M. and Keeling, P.J. 2008.  Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi. J.Euk. Microbiol. 55(2):131-133. [Link]

    Kaneshiro,E.S.,Cali, A.,Cushion,M.T., Lindsay,D.S., Marciano-Cabral,F., Mead,J.R., Weiss,L.M. 2006. The international workshops on opportunistic Protists. J.Euk. Microbiol. 53:S1-S7. [Link]

    Takvorian, P.M., Buttle, K., Mannella, C.A., Weiss, L.M., Cali, A.  2006.  High Voltage Electron Microscopy and Computerized Tomography: New Approaches to Study Microsporidian Spore Internal Organization. J.Euk. Microbiol. 53:S55-S57. [Link]

    Ghosh, K., Takvorian, P. M., Cali, A., Weiss, L.M.  2006 . Heterologous Expression of an Encephalitozoon cuniculi Aquaporin in Xenopus Oocytes. J.Euk. Microbiol. 53:S72-S73. [Link]

    Xu, Y., Takvorian, P.M., Cali,A., Zhang, H., Orr, G., Weiss,, L.M.  2006.  Identification of a new spore wall protein from Encephalitozoon cuniculi. Infection and Immunity. 74: 239-247. [Link]

    Ghosh, K., Cappiello, C.D., McBride, S.M., Occi, J.L., Cali, A., Takvorian, P. M., McDonald, T.V., Weiss, L.M. 2006.  Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidian pathogenic to humans.  Int. J. Parasitol. 36: 57-62. [Link]

    Cali, A. 2006.  Microsporidia.  In: Waterborne Pathogens (AWWA Manual M48 second edition) American Water Works Association, Denver, Colorado. p. 221-228.

    Gamble, K.C., Garner,M.M., West, G., Didier,E.S., Cali, A., Alvarado,T.P.  2005. Kyphosis associated with microsporidial myositis in San Marcos salamanders (Eurycea nana). J. Herpetologic Medicine and Surgery.  15(4):14-18. [Link]

    Cali, A., Weiss, L.M., and Takvorian, P.M.  2005. An Analysis of the Microsporidian Genus Brachiola, with Comparisons of Human and Insect Isolates of B. algerae. J.Euk. Microbiol. 51:678-685. [Link]

    Cali, A., Weiss, L.M., and Takvorian, P.M.  2005. A review of the development of two types of human skeletal muscle infections from Microsporidia associated with pathology in invertebrates and cold-blooded vertebrates.  Folia Parasitologica, 52:51-61. [Link]

    Takvorian, P.M., Weiss, L.M., and Cali, A.  2005.  The early events of Brachiola algerae infection: spore germination, sporoplasm structure, and development within host cells. Folia Parasitologica, 52:118-129. [Link]

    Zhang, H., Huang, H., Cali, A., Takvorian, P.M., Feng, X., Zhou, G. and Weiss, L.M.  2005.  Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis. Folia Parasitologica, 52:182-192. [Link]